Name: ELAC2 Rabbit Polyclonal antibody
Brand: Proteintech

Tested Applications

Applications:

WB, IF, ELISA
Application not tested? Please see our Guarantee

DU 145 cells were subjected to SDS PAGE followed by western blot with 10071-1-AP (ELAC2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Species specificity:

human, mouse, rat

Positive WB detected in:

DU 145 cells, HeLa cells, HepG2 cells

Recommended dilution:

WB : 1:200-1:1000

Product Information

Source:

Rabbit

Purification method:

Antigen affinity purification

Isotype:

IgG

Storage:

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Immunogen Information

Immunogen:

ELAC2 fusion protein Ag0105

Full name:

elaC homolog 2 (E. coli)

Calculated molecular weight:

92 kDa

Observed molecular weight:

92 kDa

GenBank accession number:

BC004158

Gene ID (NCBI):

60528

Gene symbol

ELAC2

Synonyms

elaC homolog 2 (E. coli), ElaC homolog protein 2, ELAC2, ELC2, HPC2, Ribonuclease Z 2, RNase Z 2, tRNA 3 endonuclease 2, tRNase Z 2

Background

Putative prostate cancer susceptibility protein (ELAC2) is encoded by HPC2/ELAC2 gene. HPC2 is a potential prostate cancer predisposition gene playing a role in genetic susceptibility to prostate cancer.It is a zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity and probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.Defects in ELAC2 may be a cause of susceptibility to prostate cancer (PC).

Showing 1- [6] of [7] Publications

Author:		Kara L Perks
Pubmed ID:		28835921
Journal:		Sci Adv
Title:		Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Application:		WB

Species:		mouse

Author:		Mineri Rossana R
Pubmed ID:		19492094
Journal:		PLoS One
Title:		How do human cells react to the absence of mitochondrial DNA?
Application:		WB

Species:		human

Author:		Brzezniak Lien K LK
Pubmed ID:		21593607
Journal:		RNA Biol
Title:		Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.
Application:		WB,IF
KD validated
Species:		human

Author:		Oliver Rackham
Pubmed ID:		27498866
Journal:		Cell Rep
Title:		Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.
Application:		WB

Species:		mouse

Author:		Zbigniew Pietras
Pubmed ID:		29967381
Journal:		Nat Commun
Title:		Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.
Application:		WB

Species:		human

Author:		Jourdain Alexis A AA
Pubmed ID:		23473034
Journal:		Cell Metab
Title:		GRSF1 regulates RNA processing in mitochondrial RNA granules.
Application:		IF

Species:		human

WB Figures

DU 145 cells were subjected to SDS PAGE followed by western blot with 10071-1-AP (ELAC2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

HeLa cells were subjected to SDS PAGE followed by western blot with 10071-1-AP (ELAC2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

HepG2 cells were subjected to SDS PAGE followed by western blot with 10071-1-AP (ELAC2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

ELAC2 Polyclonal antibody 7 Publications

Rabbit Polyclonal| Catalog number: 10071-1-AP